The 1st acidity is quite strong for a carboxylic acid because the conjugated base is strongly stabilised by resonance and also stabilised with the hydrogen bonding which take … Duis pulvinar non magna ac viverra. Values are generally displayed in milligram per kilo soil (dry weight). The Agency thus cannot guarantee the correctness of the information displayed. poly(ethylene-alt-maleic anhydride) in terms of both its physical behaviour and chemistry. Note: Registrants can also select ‘other’ as the type of density. In fumaric acid the carboxylic acid groups are trans (E) and in maleic acid they are cis (Z). Maleic acid (MA) is a dicarboxylic acid that undergoes esterification with ethanol in the presence of cation-exchange resin catalysts to form diethyl maleate. Data from all dossiers registered and the Classifications and Labelling Inventory (C&L) for the same substance are used to generate the Brief Profile. 3) Calculate the total … Fusce eget lorem sed purus tempus blandit. Bioaccumulation factor (aquatic species) provides substance information on the substance’s bioaccumulative properties not taking account the dimensions. If more than one numerical result is available per endpoint, the range of results (min-max, RANGE method) will be displayed. Data is generally displayed in milligram per kilo bodyweight. Maleic anhydride rapidly hydrolyzes to form maleic acid in the presence of water and hence environmental exposures to maleic anhydride itself are unlikely. The Candidate List includes substances that are subject to additional protocols and reporting obligations and which may eventually be included in the Authorisation list, further limiting their use. pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. 110-16-7 - VZCYOOQTPOCHFL-UPHRSURJSA-N - Maleic acid [NF] - Similar structures search, synonyms, formulas, resource links, and other chemical information. Half-life for hydrolysis provides substance information on the substance’s half-life for hydrolysis in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. It derives from a maleic acid. Warning! Short-term EC50 or LC50 for soil microorganisms provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of soil microorganisms in the test, generally displayed in milligram per kilo soil (dry weight). Oxidation reduction potential in mV provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature measured in °C. The % is based on count of values provided. Autoflammability / Self-ignition at 101 325 Pa provides substance information on the substance’s self-ignition temperature in °C at a pressure of 101 325 Pa. H atm provides substance information on the substance’s Henry’s Law Constant in atm at temperature measured in °C and a pressure measured in Pascal. This substance is used in the following products: pH regulators and water treatment products and laboratory chemicals. solubility 95% ethanol: soluble0.46g/10 mL, clear, colorless pka … Pre-registration allows companies to continue manufacturing and importing their. Long-term EC10 or LC10 or NOEC for birds provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the birds in the test, or the no observed effect concentration for birds. Processable data for study results is prioritised by endpoint conclusion: the most conservative value is displayed. EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. Values are generally displayed in milligram per litre. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). Translated names gives the names in different EU languages, where available to ECHA. EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram (dry weight). Structure, properties, spectra, suppliers and links for: Maleic acid, 110-16-7. Other identifiers gives any other non-name identifiers available for ths substance. To have more information on impurities relevant to classification you can consult the C&L Inventory entry for the substance, or the disseminated registration dossier. Maleic acid is more soluble in water, than fumaric acid. List of substances subject to the POPs Regulation - Indicates if the substance is included in the POPs Regulation. The availability of additional data beyond the five results displayed is indicated by (…).Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). The Restriction list describes the conditions for the manufacture, placing on the market or use of certain substances, either on their own or in mixtures or articles. Table of Acids with Ka and pKa Values* CLAS Acid HA A-Ka pKa Acid Strength Conjugate Base Strength Hydroiodic HI I-Hydrobromic HBr Br-Perchloric HClO4 ClO4-Hydrochloric HCl Cl-Chloric HClO3 ClO3-Sulfuric (1) H2SO4 HSO4-Nitric HNO3 NO3-Strong acids completely dissociate in aq solution (Ka > 1, pKa … This section displays the values related to reproductive toxicity from all registered dossiers for the substance. The recommendations are based on the precautionary statements provided in REACH registration dossiers. Release to the environment of this substance can occur from industrial use: formulation of mixtures. Registrant can provide information on the long and acute/short term exposure for both systemic and local effects of inhalation exposure of workers and/or general population by selecting one of the following hazard assessment conclusions: Prioritisation of display occurs based on the order above. The information has not been reviewed or verified by ECHA or any other authority. In that case, the ATP (Adaptation to Technical Progress) number is displayed. If so, the data provided is not processed for the Brief Profile. If more than one value is found for this section, the range of min-max values will be displayed here. Seven carboxylic acids are separated based on their polarity and pKa values. Solubility in organic solvents / fat solubility. The availability of additional data beyond the five results displayed is indicated by (…). Data is generally standardised and displayed in milligram per litre/cubic metre. If more than one numerical result is available per endpoint, the range of results (min–max) and range of experimental conditions will be presented (RANGE method). Phototransformation in water provides information on the substance’s phototransformation in water in seconds/minutes/hours/days/weeks/months/years. Processable data for summary is prioritised by test species (see list below) and subsequently further prioritised by the dose descriptor. A distinct classification and labelling corresponds to each Index number. Please see the registered dossiers for substance information for the following endpoints: The ’Substance identity’ section links substance identification information from all databases that are maintained by ECHA. If in eyes: rinse cautiously with water for several minutes. Note: Registrants can also select ‘other’ as the picklist conclusion. Can Comelles-Sud 08292 Esparreguera Barcelona Spain, Richard Baker Harrison Ltd., Albion Street Failsworth M35 0FP Manchester United Kingdom, SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany, TCL GLOBAL BV as ONLY REPRESENTATIVE OF THIRUMALAI CHEMICALS LIMITED, Saturnusstraat 46-62 2132 HB Hoofddorp Netherlands, TEXTILCOLOR GmbH (OR), Schlossgartenstrasse 2 72793 Pfullingen Baden-Wuerttemberg Germany, TFL France SAS, 4, rue de l'industrie 68333 Huningue Cedex France, THOR GmbH, Landwehrstrasse 1 D-67346 Speyer Rheinland-Pfalz Germany, Grupa Azoty Zakłady Azotowe Kędzierzyn Spółka Akcyjna, skr. If more than one result with the same value, data is further prioritised by test type and endpoint conclusion. The information provided in the free-text fields is not published in the Brief Profiles. 1.5), Extremely insensitive which do not have a mass explosion hazard (Div. Maleic acid is a weak diprotic acid with : pKa1 = 1.87 pKa2 = 6.07 A 10.00 mL solution of 0.1000 M maleic acid is titrated with 0.1000 M NaOH. It is very polar in nature due to the presence of two ionizable groups. Precautionary measures and guidance on safe use concern the use and handling of the specific substance, not of the presence of the substance in other articles or mixtures. By summarising this information in a single page, ECHA aims to make this information accessible in a user-friendly way in line with the Agency’s goals and standards. Wash with soap and water. This section summarises the values related to toxicity to aquatic plants (other than algae) from all registered dossiers for the substance. All values are from Martell, A. E.; Smith, R. M. Critical Stability Constants, Vols. Pre-registration – indicated if the substance is included in the list of pre-registered substances. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header. Under specific conditions, a registrant can claim confidentiality of their identity. EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram sediment (dry weight). If so, the data provided is not processed for the Brief Profile. The Agency thus cannot guarantee the correctness of the information displayed. EC10 / LC10 or NOEC for marine water algae provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water algae or the no observed effect concentration for marine water algae. This section displays the values related to endocrine disrupter mammalian screening from all registered dossiers for the substance. Authorisation list (Annex XIV) – indicates if the substance is included in the Authorisation List. The use information is displayed per relevant life cycle stage of the substance. Type of study provided This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications. ? Relative density at 20 °C provides information on the substance relative density at 20 °C. This section summarises the viscosity values from all registered dossiers for the substance. If so, the data provided is not processed for the Brief Profile. Air & Water Reactions Soluble in water. This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only. it can move down and push the double bond of its neighbour oxygen up, giving it the negative charge. This section displays the values (see below) related to toxicokinetics, metabolism, and distribution from all registered dossiers for the substance. This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. disodium tetraborate EC no. This substance has an industrial use resulting in manufacture of another substance (use of intermediates). It has two carboxylic acid fragments with pKa of 1.94 and 6.22. If so, the data provided is not processed for the Brief Profile. Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. Solubility in organic solvents at 20°C provides substance information on the substance solubility in organic solvents in gram per litre at a temperature of 20°C. More about CAS and the CAS registry can be found here. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). Substance evaluation – indicated if the substance is or was included in the Community rolling action plan (CoRAP). Store this substance in a well-ventilated place; locked up; in a well-ventilated place and keeping container tightly closed. Examples include recommended measures on fire-fighting, transport, recycling and disposal. If more than one DNEL/DMEL is available the most conservative (i.e. Use descriptors were adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes description as in ECHA guidance chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. clothing, mattress, curtains or carpets, textile toys) and leather (e.g. If impurities and/or additives have been identified, an informative sentence is displayed below the graphic. By summarising the endpoint study data, ECHA aims to make this information accessible in a user-friendly way in line with the Agency’s goals and standards. The Ka values of maleic acid, H 2 OOCCHCHCOO, are : Ka1 = 1.5x10-2; Ka2 = 2.6x10-7. LC50 for marine water algae provides substance information on the substance’s lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre. Close Find out more on how we use cookies. If the substance has no EC number attributed, ECHA will attribute a list number. The ‘Properties of concern’ section shows ECHA-assigned graphical indicators for certain substance properties that are regarded as critical for human health and/or the environment based on the information provided to the Agency. Values are generally displayed in milligrams per kilogram (dry weight). If the substance is classified under more than one CLH entry (e.g. Impurities or additives: When a specific critical property is associated with compositions with impurities and/or additives, the respective critical property icon has a * associated. This main layer contains sublayers for the chemical formula, atom connections and hydrogen atoms. This section summarises the density values from all registered dossiers for the substance. When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. 102 72072 Tuebingen Germany, ESIM Chemicals GmbH, St.-Peter-Strasse 25 4020 Linz Austria, LERG S.A., Pustkow-Osiedle 59 D 39-206 Pustkow 3 podkarpackie Poland, Merck Schuchardt OHG, Eduard-Buchner-Str. Degradation rate constant (OH Radicals) provides substance information on the substance’s degradation rate constant with OH Radicals as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1. pseudo-igniarius), lichen, and Iceland moss. The regulation aims improve the protection of human health and the environment from the risks that can be posed by chemicals, while enhancing the competitiveness of the EU chemical industry. Data is generally standardised and displayed in milligram per kilo soil (dry weight). LC50 for freshwater algae provides substance information on the substance’s lethal concentration for 50% of the freshwater algae in the test, displayed in generally milligram per litre. Its chemical formula is HO2CCHCHCO2H. Half-life in water provides substance information on the substance’s half-life in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C. Classifications under REACH have to be supported by data (support studies). Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below. Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, in processing aids at industrial sites and of substances in closed systems with minimal release. In case the substance classification is not harmonised and the substance is not registered the properties are derived from classifications provided in CLP notifications. The purpose of the information provided under this section is to highlight in a readable format the substance hazardousness. EC10 / LC10 or NOEC for marine water plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water plants or the no observed effect concentration for marine water plants. level’ as the dose descriptor. EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment,  generally displayed in milligrams per kilogram (dry weight). In the present study, PMA … RST is the consecutive number of the substance in the series ABC. Registrants can identify their substance as being a mono-constituent substance, multi-constituent substance, UVCB, polymer or specify another type. Data is generally displayed in milligrams per kilogram bodyweight per day. If so, the data provided is not processed for the Brief Profile. Thirdly the display of data is prioritised by unit. It is a mild and relatively harmless acid … The T g, as indicated by the peak in tan δ, does not show any large increase from the anhydride modification, as shown in Figure 4.23. Registrants can register their substance oxidising properties as: This section summarises the oxidation reduction potential values from all registered dossiers for the substance. However, branches other than methyl may be present. This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications. 2-Hydroxy-2-propyl radical reacts with highly different rate coefficients (k) with the three protonation forms of maleic and fumaric acids. 1.6), oxidising: maximum burning rate equal or higher than reference mixture, oxidising: vigorous reaction in preliminary test. Thirdly the display of data is prioritised by units. The POPs regulatory processes identified for the Brief Profile are: Classification, Labelling and Packaging (CLP)The CLP Regulation (1272/2008) entered into force on 20 January 2009. This section summarises the values related to aquatic/sediment bioaccumulation in all registered dossiers for the substance. Degradation rate constant with OH radicals provides substance information on the substance’s degradation rate constant with OH Radicals as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1. Values are generally displayed in milligram per litre. Registrants can register their substance’s bioaccumulation properties as: Registrants can register their substance’s oral/dermal/inhalation absorption rate values in percentages. EC10 / LC10 or NOEC for freshwater plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater plants or the no observed effect concentration for freshwater plants. the level of agreement, in substance classification between the REACH registrants (dark blue bar) and CLP notifiers (light blue bar), as well as between the notified classifications and the approved harmonised classification. A 50.0 mL sample of 0.13 M of maleic acid is titrated with 0.10 M NaOH. CAS 110-16-7, EC Number 203-742-5, chemical formula HOOCCH=CHCOOH. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. The aim is to display the lowest values reported as causing the most adverse effects, and hence the broadest possible safety margins for the substance. This section summarises the dissociating values from all registered dossiers for the substance. Registrants can register their substance explosiveness as: Explosiveness. More detailed information is available in the dossiers. If so, the data provided is not processed for the Brief Profile. Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. Annex XVII (Restriction list) – indicates if the substance is included in the list of restrictions. Dossier evaluation – indicated if at least one registered dossier for the substance has been evaluated under REACH for compliance check or testing proposal evaluation and associated decision(s) published on the ECHA website. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. If there is more than one result with the same value, data is further prioritised by test type and endpoint conclusion. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. Values provided in ppb and Vol% are provided separately. For example, diethyl malonate is malonic acid's diethyl ester. COD provides substance information on the substance’s COD values displayed in O2 (milli)gram per gram test material. Registrants can report substance information on viscosity as: Static viscosity at 20°C provides substance information on the substance’s (static) viscosity per square millimetre per second at a temperature of 20°C. SMILES notations are comprised of atoms (designated by elemental symbols), bonds, parentheses (used to show branching), and numbers (used for cyclic structures). The Ka values of maleic acid, HOOCCHCHCOOH, are shown below: Ka1 = 1.5e-2 Ka2 = 2.6e-7 A 50.0 mL sample of 0.13 M of maleic acid is titrated with 0.10 M NaOH. Maleic acid is an organic compound which is a dicarboxylic acid (molecule with two carboxyl groups). Values are generally displayed in milligram per kilo soil (dry weight). conveniently enough (which isn't the case for … 3D. Vivamus mauris lorem, fringilla at diam a, laoreet consequat eros. Applicant’s summary and conclusion – Interpretation of results (dermal). Long-term EC10 or LC10 or NOEC for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the terrestrial plants in the test, or the no observed effect concentration for terrestrial plants.

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